Association of rs7903146 TCF7L2 (C/T) Gene Polymorphism and Type 2 Diabetes Mellitus in Pakistani Population

Dalhat, Mahmood and Bello, Haris and Ibrahim, Bashiru and Labbo, Abdullahi (2017) Association of rs7903146 TCF7L2 (C/T) Gene Polymorphism and Type 2 Diabetes Mellitus in Pakistani Population. Journal of Applied Life Sciences International, 14 (4). pp. 1-7. ISSN 23941103

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Official URL: https://doi.org/10.9734/JALSI/2017/37411

Abstract

Among various genetic determinants of type 2 DM (T2DM), TCF7L2 (transcription factor 7 like 2) polymorphisms are among the few verified genetic variants with large effects on the risk of T2DM in different populations. In the current study, the single nucleotide polymorphism (SNP) rs7903146 (c.382-41435C>T) was screened in 322 T2DM cases and 226 controls by genotyping using amplification refractory mutation system-polymerase chain reaction (ARMS-PCR). The TCF7L2 SNP was found to be associated with T2DM; (odd ratio [OR] = 2.72; 95% confidence interval [CI] 2.00-3.71, P = 6.65×10-12). Therefore, we report the role of TCF7L2 variant in individuals with T2DM in Pakistani population.

Item Type:	Article
Subjects:	Archive Science > Biological Science
Depositing User:	Managing Editor
Date Deposited:	06 May 2023 09:17
Last Modified:	18 Jun 2024 07:42
URI:	http://editor.pacificarchive.com/id/eprint/794

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