Role of IL-33 and IL-1α in Ovarian Cancer Metastasis

Aim: The current study conducted with aims to evaluate the levels of various inflammatory cytokines in women affected by ovarian cancer.

Methods: Case-control study was conducted from 1st January 2018 to 4th March 2018 among women affected by ovarian cancer in Institute of Molecular Biology and Biotechnology, The University of Lahore, Pakistan. Ovarian cancer patients (n=50) and control individuals (n=50) were included in present study. Serum was separated from patients and control individuals from which levels of various interleukins (IL-6, IL-33, IL-8, IL-10, IL-1α) and TNF-α were measured by ELISA kit method.

Results: The results of present study explain that increased levels of IL-10, IL-6, IL-8 and TNF-α were recorded in women affected by ovarian cancer in contrary with control individuals. Elevated trend of IL-33 and IL-1α were recorded in ovarian cancer patients (9.02±2.55 pg/ml and 8.44±2.55 pg/ml) in contrary with healthy group (3.88±1.02 pg/ml and 3.56±1.32 pg/ml) with statistical significant p-value=0.000.

Conclusion: Study has concluded that inflammatory cytokines particularly IL-1α and IL-33 are major source of inflammatory pathway in the development of ovarian cancer invasion, proliferation and metastasis.