TONEKABONI, Seyed Hasan and JAFARI, Narjes and MANSOURI, Mahboubeh and JABBEHDARI, Sayena and EFTEKHARI, Rahil and CHAVOSHZADEH, Zahra and ABDOLLAH GORJI, Fatemeh and MESDAGHI, mehrnaz (2017) HLA-B*1502 in Iranian Children with Anticonvulsant Drugs-Induced Skin Reactions. Iranian Journal of Child Neurology, 11 (2). pp. 26-30.
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Abstract
Objective
Anticonvulsant drugs can cause various forms of skin drug reactions, ranging from exanthema to severe blistering reactions. An association between HLA-B*1502 allele and severe skin reactions have been reported.
Materials & Methods
Fifteen patients with severe skin reactions following treatment with anticonvulsant drugs (Carbamazepine, lamotrigine, phenobarbital, primidone) and 15 controls (age-matched epileptic patients taking similar anticonvulsants without drug eruption) were included. They were referred to Mofid Children’s Hospital in Tehran, Iran, between Jan 2012 to Jan 2014. Genomic DNA was extracted from peripheral blood of all patients and HLA- B*1502 genotype was detected by real-time PCR.
Results
None of the patients was positive for HLA- B*1502, but two patients in control group had positive HLA- B*1502.
Conclusion
The HLA- B*1502 is not correlated with severe anticonvulsant drugs -induced skin reactions in Iranian children.
| Item Type: | Article |
|---|---|
| Subjects: | Archive Science > Medical Science |
| Depositing User: | Managing Editor |
| Date Deposited: | 22 Mar 2023 09:13 |
| Last Modified: | 02 Oct 2024 07:22 |
| URI: | http://editor.pacificarchive.com/id/eprint/429 |
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