Radioiodination of Cephalexin with 125I and Its Biological Behavior in Mice

El-Bary, A.Abd and Amin, A.M. and El-wetery, A. and Saad, S. and Shoukry, M. (2012) Radioiodination of Cephalexin with 125I and Its Biological Behavior in Mice. Pharmacology & Pharmacy, 03 (01). pp. 97-102. ISSN 2157-9423

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Official URL: https://doi.org/10.4236/pp.2012.31014

Abstract

A procedure for radioiodination of Cephalexin with iodine-125 was carried out via an electrophilic substitution reaction. Using 3.7 MBq of Na125I, 200μl of cephalexin as substrate, 200 μl of iodogen as oxidizing agent in acetone at 40°C for 20 min, a maximum radiochemical yield of 125I-Ceph (95%) was obtained. The labeled compound was separated and purified by means of high-pressure liquid chromatography (HPLC). The biological distribution in normal and inflamed (septic and aseptic) mice indicates the suitability of radioiodinated cephalexin for imaging of inflammation

Item Type:	Article
Subjects:	Archive Science > Chemical Science
Depositing User:	Managing Editor
Date Deposited:	03 Mar 2023 10:45
Last Modified:	26 Jul 2024 07:20
URI:	http://editor.pacificarchive.com/id/eprint/300

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