Adly, Amira Abdel Moneim and Ismail, Eman Abdel Rahman and Elsayed, Gina Gergis Abd and Ebeid, Fatma Soliman Elsayed (2022) Predictors of Outcome in Pediatric Immune Thrombocytopenia: Relation to Thrombopoietin Levels. Asian Hematology Research Journal, 6 (3). pp. 150-164.
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Abstract
Background: It is not easy to predict the course of immune thrombocytopenia (ITP) at the time of diagnosis.
Aim: This prospective study investigated the possible predictors of ITP outcome in children and adolescents including the diagnostic potential of thrombopoietin (TPO).
Methods: Seventy pediatric patients with ITP were studied; 45 had chronic ITP and 25 were newly diagnosed and were followed-up for 3 months. Complete blood count and TPO levels were assessed.
Results: Chronic ITP patients were older (p<0.001), presented more frequently at age >5 years (p=0.027), had higher initial platelet count (p=0.005) but less likely to have platelet count >100 x 109/L after 4 weeks from diagnosis (p=0.017) and frequently used a third line of treatment (p=0.007). After 3 months follow-up of the 25 newly diagnosed ITP patients, 16 entered in a complete remission and they were younger than 5 years and had lower initial platelet count, higher platelet count after 4 weeks from diagnosis, and less frequently used corticosteroid as a second line of therapy compared with the 9 patients who developed persistent ITP. Increased TPO levels were found among patients with persistent ITP and those who experienced relapse. TPO levels were inversely related to platelets count.
Conclusions: The predictors of progression to persistent ITP and chronicity among our pediatric patients were age of onset > 5 years old, high initial platelet count, low platelets count 4 weeks after diagnosis and higher baseline TPO levels which could be used as a serum biomarker of megakaryopoiesis to predict therapeutic response.
Item Type: | Article |
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Subjects: | Archive Science > Medical Science |
Depositing User: | Managing Editor |
Date Deposited: | 20 Jun 2023 05:07 |
Last Modified: | 18 Jun 2024 07:42 |
URI: | http://editor.pacificarchive.com/id/eprint/1226 |